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DaxibotulinumtoxinA, also known as DAXI, or Daxxify, is the newest long-lasting neuromodulator for smoothing lines in the upper face. The makers of DAXI, Revance, have created an injectable that can last up to twice as long as conventional neuromodulators like Botox, Jeuveau, Xeomin, and Dysport. This attribute is sure to pique the interest of many patients who want their aesthetic results to be more long-lasting.
Newly approved by the FDA, the highly-anticipated Daxxify formulation achieves wrinkle-smoothing results like other neuromodulators by disrupting communication between facial muscles and the brain. Dynamic wrinkles and lines are a common issue in the upper third of the face. We see them when we furrow our brows (glabellar lines), when we raise our eyebrows (forehead lines), and when we squint (lateral canthal lines). All of these areas of the upper face can be targeted successfully with Daxxify!
To experience this brand new neuromodulator for yourself, book a personal consultation with a facial rejuvenation expert at Beleza Plastic Surgery to discuss what DAXI can do for you. Led by board-certified plastic surgeon Dr. Anna Wooten, our team of nurses and aestheticians can help you revitalize your face for smoother, younger-looking skin. Call our Sewickley, Pennsylvania location at (724) 759-7777, our downtown Pittsburgh offices at (412) 877-9388, or fill out an inquiry form on our website.
- 1 About Neuromodulators
- 2 How is Daxxify Different?
- 3 Benefits of Daxxify
- 4 Candidates
- 5 Personal Consultation
- 6 Daxxify Injectable Procedure
- 7 Results
- 8 Corresponding & Complementary Procedures
- 9 Cost of DAXI in Sewickley, PA
- 10 FAQ
- 11 References
Daxxify is the newest, most advanced neuromodulator on the market. For over 30 years, botulinum toxin type A (BoNTA) has been used to successfully treat signs of aging in millions of procedures worldwide. There are recognizable brand names, most notably Botox; a neuromodulator that has strong brand recognition, even among those unfamiliar with facial rejuvenation. These injectables are a particularly effective way to treat dynamic wrinkles and lines, or those that are caused by repeated facial expressions. And, as one of the most expressive areas of the face is the upper third, many people seek treatments that can smooth away deeper expression lines that have “set in” over time.
Is Your Face Truthfully Expressing Your Emotions?
Over time, repeated facial movements in the same places cause deeper, more permanent rhytides (lines). In particular, glabellar frown lines become indented between the brows. They may even remain when we are not frowning. As well as being an indicator of age, these lines may also be misinterpreted by others as anger, irritation, concern, or even exhaustion. (1)
BoNTA treatments are an attractive choice for many people because they’re minimally invasive, they don’t cost as much as surgery, and they produce noticeable wrinkle-reducing results patients can be proud of. However, what has remained largely unchanged in this time period is how long these aesthetic results last. Research into previously approved BoNTA treatments has consistently shown that the duration of their effects lasts no longer than 3 to 4 months (12–16 weeks). (2) With Daxxify, results can last significantly longer!
How is Daxxify Different?
DAXI, or Daxxify, is a newly FDA-approved product that contains highly purified DaxibotulinumtoxinA, a subtype of botulinum toxin. It’s the very first neuromodulator to be formulated with a unique protein (RTP004) instead of human serum albumin. (3) Human serum albumin is a stabilizer that protects the injectable during shipping and storage. Research suggests that the addition of the RTP004 protein in DAXI makes results last longer than those from conventional injectable neuromodulators.
The Most Anticipated Long-Lasting Neuromodulator
Daxxify provides the long-lasting results patients have been waiting for! Studies show the unique protein in DAXI causes the botulinum toxin to stay close to the nerves at the injection site. It is suggested that this attribute makes the wrinkle-smoothing effects of DAXI last longer. (3)
Benefits of Daxxify
- Lasts longer than any other neuromodulator
- Smooths crow’s feet, frown lines, and horizontal forehead lines
- Can prevent future wrinkles from developing
- Fast, convenient, and comfortable
- Minimally-invasive in-office treatment
- Results can last up to 6 months
The new DAXI treatment for wrinkles and lines in the upper face saves the hassle of frequent trips to the office for “touch-ups”. With Botox and other injectables, it’s often necessary to come in every few weeks to maintain the results you want. But with Daxxify, patients may only need to visit once or twice a year!
In one DAXI study, 95.7% of participants were somewhat satisfied, satisfied, or very satisfied with their results after four weeks, with the highest number of participants describing themselves as very satisfied! (1)
Testing shows that DAXI is suitable for a wide variety of candidates. If you have noticeable dynamic wrinkles around your eyes, between your brows, and on your forehead, and you want a treatment that can last longer than Botox, DAXI could be the ideal fit for your needs. Apart from being in good overall health, Daxxify recipients should not:
- Have an active skin disease or infection at the injection sites
- Have a history of clinically significant bleeding disorders
- Get concurrent laser or light treatments, microdermabrasion, or chemical peels
- Have a known allergy to any of DAXI’s ingredients
- Be prone to strong allergic reactions (anaphylaxis)
- Be pregnant, breastfeeding, or have a neurological disorder
At the Beleza Plastic Surgery medispa, our facial rejuvenation experts meet with each prospective patient before they book their treatment. This is to ensure it’s the right choice for their aesthetic goals. It also helps us assess the areas for treatment, and includes some questions and forms regarding your medical history and your history of prior facial rejuvenation treatment. Contact us today to book your one-on-one session at Beleza with our licensed medical professionals!
Daxxify Injectable Procedure
Your DAXI procedure at Beleza will be performed by a trained nurse injector. Each of our nurses and aestheticians is a specialist trained in human facial anatomy and the optimal injection locations for the most effective results. Prior to your session, we may ask you to follow some directions, such as coming to your appointment without any makeup on your face. Depending on your treatment plan, one of our nurse injectors will target crow’s feet, glabellar lines and/or forehead lines and carefully inject the muscles in each area with the DAXI formulation. After your procedure, you will be free to leave our office and continue with your day.
As with Botox, patients should expect some mild residual swelling at the injection sites. There may be some tenderness and redness which is common, and will dissipate over time. Any discomfort can be managed with ice packs and over-the-counter acetaminophen (Tylenol). We advise not laying down flat for 4 hours after injections, and avoiding exercise or aerobic activity for 24 hours. Most patients see results appear after 3 days. (4) You may expect your treated areas to be wrinkle-free for up to six months!
Corresponding & Complementary Procedures
As an alternative to Daxxify, Botox by Galderma is the standard neuromodulator treatment for dynamic lines and wrinkles in the face. It’s used by millions worldwide each year because it’s a fast procedure, there’s no downtime, and it produces great results. Patients can use Botox to smooth away rhytides throughout the face. Like DAXI, it is particularly effective for the correction of horizontal forehead lines, crow’s feet, and glabellar lines.
Made by Evolus, Jeuveau is an alternative neuromodulator injection to Daxxify and Botox. It has the same goals in that it smooths wrinkles and lines in the face to help you look and feel more youthful. Patients can discuss their injectable options, and find the best one for their individual beauty goals at their personal consultation.
The aim of dermal fillers is to smooth and plump facial tissue. They are particularly useful in the reduction of the appearance of nasolabial folds, and lines in the lower face, chin, lips, and around the mouth. We offer the Restylane family of hyaluronic acid fillers, including the classic Restylane formula, Restylane Lyft, Restylane Kysse, Restylane Defyne, and Restylane Refyne. Patients with severe wrinkles, folds, and lines may consider the poly-L lactic acid (PLLLA) filler Sculptra.
Cost of DAXI in Sewickley, PA
Your DAXI injectable treatment plan will be unique to you. Therefore, the cost of the procedure will vary. Speak to our professional team of skin rejuvenation experts about the benefits of DAXI at your personal consultation. Book now by calling our Sewickley office at (724) 759-7777 or fill out this form on our website.
Follow the Beleza Plastic Surgery blog for more information about med spa treatments and aesthetic surgical procedures from Dr. Wooten and her team.
Is Daxxify better than Botox?
Daxxify is the newest injectable treatment for facial rejuvenation. Many studies have shown that DAXI can last longer than Botox. Typically, results from Botox last 3-4 months. Results in research studies showed that Daxxify results could last up to 6 months.
How long does a Daxxify injectable treatment session take?
Daxxify treatment sessions are comparable to other injection procedures. Depending on your treatment plan, you can expect the process to be complete in under 20 minutes.
Can I have laser treatments on the same day as DAXI?
Some procedures, like IPL or a light micropeel, may be done on the same day as injection, as long as it is done before injection. Some of our other laser treatments (like Morpheus8 or ResurFX) are better suited to be done separately to ensure great results. The important thing to remember when combining treatments is to consult your Beleza provider and be honest with them about other treatments and procedures you are having done. This is to avoid complications. After all, you are investing time and money into yourself so that you look and feel your absolute best, and we want to support you in that journey.
- Bertucci V, Solish N, Kaufman-Janette J, et al. DaxibotulinumtoxinA for Injection has a prolonged duration of response in the treatment of glabellar lines: Pooled data from two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2). Journal of the American Academy of Dermatology. 2020;82(4):838-845. doi:10.1016/j.jaad.2019.06.1313 https://www.jaad.org/article/S0190-9622(19)32459-4/fulltext
- Glogau R, Kontis TC, Liu Y, Gallagher CJ. Progressive Improvement in Static Glabellar Lines After Repeated Treatment With DaxibotulinumtoxinA for Injection. Dermatologic Surgery. 2021;47(12):1579-1584. doi:10.1097/dss.0000000000003211 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612903/
- Solish N, Carruthers J, Kaufman J, Rubio RG, Gross TM, Gallagher CJ. Overview of DaxibotulinumtoxinA for Injection: A Novel Formulation of Botulinum Toxin Type A. Drugs. 2021;81(18):2091-2101. doi:10.1007/s40265-021-01631-w https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648634/
- Carruthers JD, Fagien S, Joseph JH, et al. DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines. Plastic and Reconstructive Surgery. 2020;145(1):45-58. doi:10.1097/prs.0000000000006327 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940025